Cocaine potentiates MDMA-induced oxidative stress but not dopaminergic neurotoxicity in mice: implications for the pathogenesis of free radical-induced neurodegenerative disorders

Peraile, I.; Granado, Noelia; Torres, Elisa; Gutiérrez López, María Dolores; Moratalla, Rosario; Colado, Isabel; O’Shea, Esther; Peraile, Inés

Publicación:
Cocaine potentiates MDMA-induced oxidative stress but not dopaminergic neurotoxicity in mice: implications for the pathogenesis of free radical-induced neurodegenerative disorders

dc.contributor.author	Peraile, I.	es
dc.contributor.author	Granado, Noelia	es
dc.contributor.author	Torres, Elisa	es
dc.contributor.author	Gutiérrez López, María Dolores	es
dc.contributor.author	Moratalla, Rosario	es
dc.contributor.author	Colado, Isabel	es
dc.contributor.author	O’Shea, Esther	es
dc.contributor.author	Peraile, Inés
dc.contributor.funder	Ministerio de Ciencia e Innovación (MICINN)	es
dc.contributor.funder	Comunidad de Madrid	es
dc.contributor.funder	Ministerio de Sanidad y Política Social	es
dc.contributor.funder	Instituto de Salud Carlos III (ISCIII)	es
dc.contributor.funder	Universidad Complutense de Madrid (UCM)	es
dc.date.accessioned	2025-01-29T13:19:48Z
dc.date.available	2025-01-29T13:19:48Z
dc.date.issued	2013-05-17
dc.description.abstract	The drugs of abuse 3,4-methylenedioxymethamphetamine (MDMA; “ecstasy”) and cocaine both increase the generation of free radicals, and in the case of MDMA, this increase in oxidative stress is involved in the dopaminergic neurotoxicity produced by the drug in mice. Oxidative stress processes are also involved in the pathogenesis of several neurodegenerative diseases.	es
dc.description.peerreviewed	Peerreview	es
dc.description.sponsorship	This work was supported by grants from Ministerio de Ciencia e Innovación, Ministerio de Sanidad y Política Social, ISCIII, and Universidad Complutense-Comunidad de Madrid: SAF2006-07045, SAF2010-21529, PI070892, PNSD 3SI/04/01, Retics RTA RD06/0001/0006 and RD06/0001/1011, CIBERNED CB06/05/0055, and UCM-CAM 910258. IP and ET received predoctoral grants from Universidad Complutense de Madrid and Ministerio de Educación y Ciencia. NG was funded by a Juan de la Cierva postdoctoral contract from Ministerio de Ciencia e Innovación.	es
dc.identifier.citation	Psychopharmacology (2013) 230:125–135	es
dc.identifier.doi	0.1007/s00213-013-3142-5
dc.identifier.other	https://link.springer.com/article/10.1007/s00213-013-3142-5	es
dc.identifier.uri	http://hdl.handle.net/20.500.12666/1044
dc.language.iso	eng	es
dc.publisher	Springer Nature	es
dc.rights.accessRights	info:eu-repo/semantics/openAccess	es
dc.rights.license	Copyright © 2013, Springer-Verlag Berlin Heidelberg	es
dc.subject	Oxidative stress	es
dc.subject	3,4-Methylenedioxymethamphetamine	es
dc.subject	Dopamine neurotoxicity	es
dc.subject	Cocaine	es
dc.title	Cocaine potentiates MDMA-induced oxidative stress but not dopaminergic neurotoxicity in mice: implications for the pathogenesis of free radical-induced neurodegenerative disorders	es
dc.type	info:eu-repo/semantics/article	es
dc.type.coar	http://purl.org/coar/resource_type/c_2df8fbb1	es
dc.type.hasVersion	info:eu-repo/semantics/publishedVersion	es
dspace.entity.type	Publication
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